Barcelona has failed in their attempt to rush Messi back to action after the talisman missed their final training session due to fitness issues and would hereby not be available to feature for the game.
The Defending Champions were without Messi last week and lost against Athletic Bilbao in the dying minutes of the encounter after Adriuz stunning strike was enough to give his team all three points.
Messi has been working his way back from a calf injury sustained after returning late to the Barca pre-season following his efforts with Argentina in the Copa America.
With Luis Suarez and Ousmane Dembele nursing injuries, there was hope Messi would be ready to return to the lineup against Betis.
Barcelona’s arch rivals, Real Madrid dropped points last night against Real Valladolid and the Catalonia based team would hope to capitalize on it by going all out against Betis.